# SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

> **NIH NIH N01** · BATTELLE MEMORIAL INSTITUTE · 2020 · $700,000

## Abstract

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized

## Key facts

- **NIH application ID:** 10213574
- **Project number:** 273201700005C-P00008-9999-15
- **Recipient organization:** BATTELLE MEMORIAL INSTITUTE
- **Principal Investigator:** BARNEY SPARROW
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $700,000
- **Award type:** —
- **Project period:** 2017-09-26 → 2020-09-25

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213574

## Citation

> US National Institutes of Health, RePORTER application 10213574, SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP (273201700005C-P00008-9999-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10213574. Licensed CC0.

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