# SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE TOXICOGENOMIC RESPONSE OF DO MOUSE CELL LINES EXPOSED TO CHEMICALS FOR THE NTP

> **NIH NIH N01** · BATTELLE MEMORIAL INSTITUTE · 2020 · $421,424

## Abstract

A critical research area cited in the Tox21 Phase 3 strategic plan is incorporation of genetic diversity in in vitro screening strategies to determine population dynamics in chemical response. This study leverages lysates collected from Diversity Outbred mouse neural progenitor cells exposed to 3 potentially neurotoxic agents at 12 chemical concentrations. In the course of this analysis, (1) key transcriptional pathways that distinguish susceptible from nonsusceptible mouse lines for each chemical, (2) points of departure for key molecular events as defined by transcriptional status, and (3) toxicodynamic variability factors that describe interindividual differences in chemical response within the Diversity Outbred (DO)  mouse population, were determined.

## Key facts

- **NIH application ID:** 10213575
- **Project number:** 273201700005C-P00008-9999-16
- **Recipient organization:** BATTELLE MEMORIAL INSTITUTE
- **Principal Investigator:** BARNEY SPARROW
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $421,424
- **Award type:** —
- **Project period:** 2017-09-26 → 2020-09-25

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213575

## Citation

> US National Institutes of Health, RePORTER application 10213575, SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE TOXICOGENOMIC RESPONSE OF DO MOUSE CELL LINES EXPOSED TO CHEMICALS FOR THE NTP (273201700005C-P00008-9999-16). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10213575. Licensed CC0.

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