# 2/2 APOL1 Long-Term Kidney Transplantation Outcomes Network- Clinical Center

> **NIH NIH U01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $307,337

## Abstract

Project Summary (Abstract)
The Columbia-Penn Clinical Consortium (CPCC) brings together an experienced multidisciplinary team of
clinical and basic scientist investigators at Columbia University Medical Center and University of Pennsylvania
Transplant Programs. The CPCC investigators have expertise in the fields of transplant epidemiology,
immunology, genetics and ethics, as well as an extensive history of collaboration with the United Network for
Organ Sharing (UNOS) and other CPCC member transplant programs. As a result, the CPCC is well suited to
recruit and retain patients for longitudinal follow up for the APOL1 Long-term Kidney Transplantation Outcomes
Research Network (APOLLO). This proposed Clinical Center will comprise of 26 pediatric and adult large,
medium and small size transplant centers and 9 organ procurement organizations predominantly in four
contiguous states (NY, NJ, CT and PA) in the northeast US. Our primary objective is to enroll all donors of
African ancestry (e.g. African-Americans and Black Hispanic) and their recipients within the consortium for
genetic and genomic studies by the APOLLO Network (Aim 1). We will follow all recruited donor-recipient pairs
with longitudinal collection of biospecimens and clinical outcomes along with pragmatic integration with Organ
Procurement and Transplantation Network (OPTN), UNOS and the United States Renal Data System
(USRDS) data (Aim 2). Our experience in the recruitment and retention of minority patients in multicenter
studies, as well as the use of innovative analytics with linkage to UNOS, USRDS and other geospatial data, will
be of benefit to the APOLLO Network. We expect that our unique design and implementation expertise to the
APOLLO study will address the hypothesis that the presence of two APOL1 risk variants is associated with
inferior allograft outcomes following kidney transplant and increases the risk of adverse renal outcomes for
affected living donors.

## Key facts

- **NIH application ID:** 10213700
- **Project number:** 5U01DK116066-05
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Sumit Mohan
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $307,337
- **Award type:** 5
- **Project period:** 2017-09-25 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213700

## Citation

> US National Institutes of Health, RePORTER application 10213700, 2/2 APOL1 Long-Term Kidney Transplantation Outcomes Network- Clinical Center (5U01DK116066-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10213700. Licensed CC0.

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