# Aging in Community Health Clinics (ACHES) Changes in Multimorbidity and Disability Among Race/Ethnic Older Adults COVID-19 Related Administrative Supplement

> **NIH NIH R01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $263,993

## Abstract

Project Summary
This work will advance our knowledge of the contributing role of specific pre-existing co-occurring chronic
disease (multimorbidity) patterns and sociodemographic factors in the likelihood of contracting COVID-19 and
experiencing adverse health-related outcomes among middle-aged and older vulnerable adults. We will
address key gaps in knowledge: (1) Are there specific multimorbidity patterns that increase risk of COVID-19
infections, and do they vary by age and race/ethnicity? (2) What is the relationship between specific
multimorbidity patterns and disease accumulation among patients with COVID-19, and does this differ by age
or race/ethnicity? (3) What is the relationship between multimorbidity patterns and experiencing more severe
COVID-19 disease course, and does that differ by age and race/ethnicity? And, (4) Are there differential
mortality risks by multimorbidity pattern among patients with COVID-19, and does age or race/ethnicity
moderate this relationship?
Our proposed research leverages clinical electronic health record (EHR) data from large networks of CHCs for
rapid evaluation of the impact of COVID-19 among people with multimorbidity. We anticipate important insights
from findings that will inform clinical processes (workflow, clinical care decision-making) and policies that serve
safety-net populations by identifying multimorbidity patterns predictive of rapid COVID-19 related health
downturns. We propose two aims to:
SA1. Identify multimorbidity patterns associated with COVID-19 diagnoses. Examine specific disease
patterns associated with diagnoses (e.g., cardiovascular, metabolic disease) and sociodemographic correlates
(e.g., age, race/ethnicity) that confer greater susceptibility to COVID-19.
SA2: Identify trajectories of adverse health-related outcomes for patients with COVID-19. Understand
the impact of COVID 19 on progression of chronic disease (i.e., multimorbidity accumulation) in patients with
various multimorbidity patterns and determine whether different patterns of pre-existing multimorbidity are
associated with greater adverse health outcomes from COVID 19 infection, such as more severe disease
course (e.g., hospital admissions, ICU admissions, inpatient days, mortality). We will also evaluate whether
sociodemographic correlates (e.g., age, race/ethnicity) are associated with greater multimorbidity
accumulation, more severe course of COVID-19, and mortality.

## Key facts

- **NIH application ID:** 10214273
- **Project number:** 3R01AG061386-03S1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Ana Roman Quinones
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $263,993
- **Award type:** 3
- **Project period:** 2019-09-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10214273

## Citation

> US National Institutes of Health, RePORTER application 10214273, Aging in Community Health Clinics (ACHES) Changes in Multimorbidity and Disability Among Race/Ethnic Older Adults COVID-19 Related Administrative Supplement (3R01AG061386-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10214273. Licensed CC0.

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