# Inflammatory mediators and beta-cell function among obese Latino youth with prediabetes

> **NIH NIH F31** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2021 · $33,320

## Abstract

PROJECT SUMMARY
 Obesity and type 2 diabetes (T2D) disparities among Latino children and adolescents represent some of
the most significant public health challenges facing society. Inflammation is associated with beta-cell
dysfunction and both are evident in obese youth with prediabetes. Lifestyle intervention is the primary
approach to preventing or delaying onset of T2D and has been effective in improving the inflammatory milieu
and beta-cell function. However, less is known about the effect of lifestyle intervention on specific pro- and anti-
inflammatory mediators associated with beta-cell dysfunction in youth. Furthermore, the relationship between
changes in pro- and anti-inflammatory mediators and changes in beta-cell function remains unexplored in
obese youth. Knowledge regarding the mechanisms by which T2D risk mediators are improved is limited due
to a lack of measurement of different anti-inflammatory mediators. Therefore, we propose a longitudinal study
that will examine the effect of lifestyle intervention on pro- and anti-inflammatory mediators in 79 obese Latino
youth with prediabetes as compared to a usual care control group of 38 obesity- and glycemia-matched Latino
youth. Understanding how changes in pro- and anti-inflammatory markers relate to changes in beta-cell
function is important to identify specific mechanisms that can be targeted in future studies. Therefore, this
study will explore the association between changes in pro- and anti-inflammatory mediators and changes in
beta-cell function in obese Latino youth with prediabetes. This proposal leverages the resources and
infrastructure of an ongoing diabetes prevention study and builds upon a transdisciplinary team of mentors to
address a critical gap in chronic disease prevention in obese Latino youth, age 12-16 years. This innovative
approach is an essential first step in the development of lifestyle interventions aimed at targeting inflammatory
mechanisms to assess changes in T2D risk in this high-risk population.

## Key facts

- **NIH application ID:** 10214563
- **Project number:** 5F31DK125037-02
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** Armando Pena
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $33,320
- **Award type:** 5
- **Project period:** 2020-08-10 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10214563

## Citation

> US National Institutes of Health, RePORTER application 10214563, Inflammatory mediators and beta-cell function among obese Latino youth with prediabetes (5F31DK125037-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10214563. Licensed CC0.

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