# Acute kidney injury among patients with chronic kidney disease

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $659,305

## Abstract

PROJECT SUMMARY
Acute kidney injury (AKI) is one of the major manifestations of kidney disease. AKI's importance is
underscored by recent studies reporting that its incidence is increasing. AKI disproportionately affects those
with chronic kidney disease (CKD), so it is compelling to embed the investigation of AKI in the largest and most
comprehensive prospective cohort study of CKD in the US, the Chronic Renal Insufficiency Cohort (CRIC)
study.
We propose to comprehensively evaluate all inpatient hospital records for all enrollees in CRIC Phases 3 and 4
(from 2013-2021) to identify episodes AKI, define their severity and examine their sequelae. CRIC was
launched over a dozen years ago as a study of the natural history of CKD. It now offers an under-utilized but
potentially unmatched opportunity to advance our understanding of the role AKI plays in shaping the natural
history of CKD. Particularly valuable is the availability of research protocol-driven collection of data and
biospecimens both before and after episodes of hospitalized AKI.
Our Specific Aims are: 1) to evaluate the associations of hospitalized AKI and its severity with subsequent rate
of loss of renal function after taking into account pre-AKI estimated glomerular filtration rate (eGFR) slope and
pre-AKI proteinuria level; 2) to evaluate the associations of hospitalized AKI and its severity with change in
proteinuria and to assess the relation between post-AKI proteinuria level and subsequent CKD progression; 3)
to define the risk of future cardiovascular events associated with hospitalized AKI and its severity; 4) to
determine the association of hospitalized AKI with changes in levels of biomarkers of injury, inflammation and
fibrosis.
Compared with all the other studies based on observational data now published in the literature, ours will have
a much more rigorous experimental design, greatly reducing residual confounding and other biases. Our
findings may challenge the current reigning paradigm that mild to moderate episodes of AKI worsen the
course/outcome of CKD.

## Key facts

- **NIH application ID:** 10214596
- **Project number:** 5R01DK114014-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Chi-yuan Hsu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $659,305
- **Award type:** 5
- **Project period:** 2018-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10214596

## Citation

> US National Institutes of Health, RePORTER application 10214596, Acute kidney injury among patients with chronic kidney disease (5R01DK114014-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10214596. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*