# Biomedical Research Core 3 - Clinical Research Core

> **NIH NIH U54** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2021 · $221,780

## Abstract

Clinical Research Core - Project Summary/Abstract
The overarching challenge in PKD is how to translate the many advances in basic scientific understanding of
the pathophysiology of PKD into the development of effective new drugs. Specific challenges include a
shrinking pool of patients available for clinical trials, lack of biomarkers in early disease, lack of widely-
available, standardized data models to harmonize diverse data sources, and limited engagement of patients
and their families in prioritizing research questions. The goal of the Clinical Research Core is to facilitate
research across the translational spectrum from T1 to T4 by PKD investigators nationwide. This will be
achieved through the development of multiple tools and resources that will be made freely available to the
research community. The specific aims are: 1) to create a consortium of academic centers across the Central
and Western regions to form an ADPKD clinical trial network; 2) to expand and continue to follow a longitudinal
cohort of young patients with early ADPKD and control subjects and collect biospecimens for biomarker
discovery; 3) create a standardized data collection instrument for PKD studies in RedCAP and software for
automated mapping into a standard data format required for registration studies; and 4) use our patient
engagement resource to identify patients' priorities for research questions and use this to inform research
strategy and directions in the PKD community.

## Key facts

- **NIH application ID:** 10214616
- **Project number:** 5U54DK126126-02
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** Alan S Yu
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $221,780
- **Award type:** 5
- **Project period:** 2020-07-15 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10214616

## Citation

> US National Institutes of Health, RePORTER application 10214616, Biomedical Research Core 3 - Clinical Research Core (5U54DK126126-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10214616. Licensed CC0.

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