# Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial Network

> **NIH NIH U01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2021 · $580,575

## Abstract

Project Summary
Using genomic variation to tailor therapeutic, preventative, and diagnostic decision-making is a
potentially transformative approach to clinical care. However, uncertainty about clinical impact
and economic value presents a critical barrier to broad adoption. The Integrated, Individualized,
Intelligent Prescribing (I3P) Clinical Trials Network includes three clinically and
sociodemographically diverse health systems to IGNITE 2: Metro General Hospital at Meharry
Medical College, Sanford Health and Vanderbilt University Medical Center (VUMC). The
Network will develop infrastructure to quickly recruit large, diverse patient populations, return
results at the time of clinical indication, and provide health care providers with understandable,
implementable guidance during the course of the trial. The first aim will develop and implement
infrastructure to efficiently conduct pragmatic clinical trials involving Genomic Medicine across
the diverse settings within I3P. The second aim proposes a randomized, pragmatic clinical trial
of multiplexed pharmacogenomics testing across the IGNITE 2 Network to establish the clinical
utility of panel testing. And finally, I3P will develop and implement an IGNITE 2 Network-wide
capability to calculate Phenotype Risk Scores across health system populations to efficiently
identify and intervene on patients likely to have a genomic diagnosis. All of the institutions
within the I3P Network will leverage their strong record of collaboration within IGNITE 1 and
other NIH funded consortia to accomplish these aims.

## Key facts

- **NIH application ID:** 10215587
- **Project number:** 5U01HG010232-04
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Joseph F. Peterson
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $580,575
- **Award type:** 5
- **Project period:** 2018-09-19 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10215587

## Citation

> US National Institutes of Health, RePORTER application 10215587, Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial Network (5U01HG010232-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10215587. Licensed CC0.

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