# Impact of Vitamin D on the Chemopreventive Efficacy of Erlotinib against Oral Cancer

> **NIH NIH R01** · ROSWELL PARK CANCER INSTITUTE CORP · 2020 · $252,300

## Abstract

Project Summary
The outbreak of COVID-19 has changed the practice of medicine in a fundamental manner resulting in
sweeping changes in healthcare virtually across all medical specialties. Dentistry, in particular, has been
dramatically affected by this pandemic, given the close `person-to-person' contact involved in delivering dental
care and treatment procedures that produce aerosols and often result in the dental health care professional
(DHCP) contact/exposure to blood, saliva and respiratory droplets. Specifically, the pandemic has led to
adaptations to diagnostic and treatment paradigms, modifications to clinical workflow and dental/oral care
delivery models. Given that the pandemic is still on-going, the magnitude of the impact of these modified oral
health care delivery models, especially in high-risk patient populations (e.g. cancer patients) is not known. This
application for a “Urgent Competitive Revision to Existing NIH Grants (Urgent Supplement)” is being submitted
in response to PA-18-935 to request supplemental funding to the R01DE024595 (PI: Seshadri, Mukund). The
research proposed in this supplement was specifically developed in response to the recent coronavirus
disease 2019 (COVID-19) pandemic to assess the impact of dental care delivery delays in cancer patients.
The proposal is of immediate and high impact to NIDCR.

## Key facts

- **NIH application ID:** 10215646
- **Project number:** 3R01DE024595-05S1
- **Recipient organization:** ROSWELL PARK CANCER INSTITUTE CORP
- **Principal Investigator:** Mukund Seshadri
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $252,300
- **Award type:** 3
- **Project period:** 2016-07-16 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10215646

## Citation

> US National Institutes of Health, RePORTER application 10215646, Impact of Vitamin D on the Chemopreventive Efficacy of Erlotinib against Oral Cancer (3R01DE024595-05S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10215646. Licensed CC0.

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