ABSTRACT 21st century changes in the healthcare sector have outpaced changes in science education. High school students who have the luxury of receiving high quality experiential education are least likely to be from racially, ethnically, or geographically diverse backgrounds. There is an urgent need to reach students least likely to be served with culturally responsive, localized science education partnerships, specifically minority and rural student populations. Without special programming, inequities in educational access will persist, and the healthcare sector will be ill-prepared for whom it is designed to serve. For the last five years, we have used an NIH Science Education Partnership Award (SEPA) to address this problem by focusing on teachers as agents of change. Our prior SEPA (2015-2020), Teachers and Students for Community-Oriented Research and Education (TSCORE), empowered teachers to engage urban high school students in Kansas through innovative teaching about health disparities and creation of model units. We found that teachers in underserved districts lacked the professional development, curricular materials and often depth of knowledge needed to implement culturally relevant, rigorous NGSS-aligned science curricula. Underserved school districts are less likely to partner with universities and industry to provide students with opportunities for experiential learning outside the classroom. And partnerships with industry are key to designing and implementing STEM educational experiences that meet the needs of a diverse population of students while preparing them for careers. With these premises in mind, we propose a continuum of educational interventions that are embedded within the existing structure of the state of Kansas Health and Bio Sciences Career Pathway. “TSCORE LIFT,” which Links Industry, Faculty, and Teachers in communities, will 1) Create community linkages among health system, university faculty, and public school teachers to offer a continuum of NGSS-aligned educational interventions across the state of Kansas Health and Bio Sciences Career Pathway. Each of five Kansas towns will have a local health system partner, a local K-INBRE university partner, and a public high school, who will work together to develop NGSS-aligned high school storylines for biology courses; a health science academy for career exploration; and a capstone course to provide work-based learning experiences that address local science and healthcare workforce needs. 2) We will empower teachers to work alongside health system and university partners to develop and implement a curricular continuum of NGSS-aligned localized science education programming through summer professional development that will mirror the rollout of the science programming; an end of grant Teacher Summit; and virtual network site to increase teachers' connectivity, resource exchange, and enable the emergence of a critical mass of practitioners focused on increasing rigorous he...