# Genomics, Biostatistics and Bioinformatics Core

> **NIH NIH P01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $210,883

## Abstract

CORE B PROJECT SUMMARY/ABSTRACT
Consistent with the Overall aims of the PPG, the Genomics, Biostatistics and Bioinformatics core (Core B) will
play a central role focused on robust identification and prioritization of candidate genes, pathways and gene
signatures in order to elucidate how HCMV encoded genes regulate cellular signaling in HPCs to contribute to
the establishment and maintenance of viral latency as well as hematopoiesis. Core B will support all five
projects and will provide biostatistics and bioinformatics assistance, as well as critical expertise and
standardization in sample and library preparation and initial confirmation to aid in prioritization of targets. Core
B is responsible for the pre-processing, integration and modeling of the diverse readouts (e.g., transcriptomics,
phosphoproteomics, secretomics etc.) generated by each project as well as across projects within the PPG.
These data will be incorporated into probabilistic pathway models to provide a rigorous and reproducible
framework for hypothesis testing. Follow-up validation and perturbation experiments will aid in the evaluation
and refinement of the modeling in an iterative manner. To ensure the data from all PPG research projects will
be generated in a standardized manner, the GBBC will play a critical role in facilitating PPG studies, managing
and integrating the diverse experimental read-outs, assessing reproducibility and guiding identification of the
most promising candidates for validation. The GBBC will regulate consistency and quality of the samples to be
sequenced by performing both CD34+ HPC infection experiments with virus mutants generated by the different
projects, and subsequent RNA isolations for RNA-seq to allow for cross-comparisons of datasets. This core will
assist in prioritization of candidates for further perturbation and validation studies. Finally, the GBBC will
provide bioinformatics and biostatistics support for PPG components throughout the “data life cycle” including
assistance with experimental design, data pre-processing, QA/QC, analysis, modeling and visualization as well
as data integration, storage, management, standards and dissemination for all data types utilized in the PPG.

## Key facts

- **NIH application ID:** 10216632
- **Project number:** 5P01AI127335-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Shannon K. McWeeney
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $210,883
- **Award type:** 5
- **Project period:** 2017-08-15 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10216632

## Citation

> US National Institutes of Health, RePORTER application 10216632, Genomics, Biostatistics and Bioinformatics Core (5P01AI127335-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10216632. Licensed CC0.

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