# 11 Solid Tumor Therapeutics Program

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2021 · $100,450

## Abstract

SOLID TUMOR THERAPEUTICS PROGRAM (STTP): PROJECT SUMMARY
The Solid Tumor Therapeutics Program (STTP) is focused on discovering somatic and germline genomic
alterations that are either shared or unique across various solid tumor malignancies, and translating these
discoveries into novel therapeutics that will improve the quality of life and survival for cancer patients. Two
fundamental thematic areas (Genomics Technologies and Discovery, and Developmental Therapeutics [DT])
were organized to promote disease-specific studies in neuro, head and neck, thoracic, gastrointestinal,
genitourinary, and gynecologic oncology. The STTP is coordinated through a leadership committee, research
meetings, seminars, retreats, and other educational activities. Training for junior investigators is implemented
through a mentorship plan and is supported through NCI-funded T32 (HD007499), K12 (CA167540), and Clinical
and Translational Scientific Award (CTSA) educational programs. We identified areas of institutional strength
and developed three research aims for the next project period. Aim 1. Develop innovative therapeutic
strategies by identifying genomic, epigenomic, proteomic, and metabolomic (‘omic) alterations that
occur in solid tumors and by mapping their spatiotemporal evolution using preclinical models and tumor
specimens. Aim 2. Determine how genomic alterations interact with immune landscapes in solid tumor
malignancies; identifying these potential synergies will improve therapeutic outcomes. Aim 3. Explore
the relationships among germline variants and their effects on cancer susceptibility and treatment in
solid tumor malignancies, and evaluate sex-specific effects on cancer biology. These aims are designed
to elucidate the effects of genetic instabilities, DNA repair defects, and specific inhibitors on solid tumor initiation,
maintenance, progression, and chemoresistance. The STTP leadership facilitates and encourages collaborative
interactions between disease-specific investigators and translational experts to promote translational and clinical
research. These interactions are achieved through working-group meetings, focus-group meetings, seminars,
and funded programs such as the NCI U54 CA224083 PDX clinical trial network and the NCI U2C CA233303
Washington University Human Tumor Atlas Research Center, which will construct detailed 4D atlases for breast
cancer, glioblastoma, and pancreatic adenocarcinoma. The STTP has 47 members from 13 departments at
Washington University School of Medicine. The STTP is supported by a total of $25.9 million direct costs in
cancer-related funding, $5.8 million in NCI funding, and $5.8 million in other peer-reviewed funding. STTP
members published 1,723 papers during 2014–2018, with 33% resulting from inter-programmatic collaborations
and 24% resulting from intra-programmatic collaborations. During 2014–2018, STTP members participated in
1,511 clinical trials, 56% of which were interventional trials. These trials enrolle...

## Key facts

- **NIH application ID:** 10217025
- **Project number:** 5P30CA091842-20
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** TIMOTHY J. EBERLEIN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $100,450
- **Award type:** 5
- **Project period:** 2001-08-02 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10217025

## Citation

> US National Institutes of Health, RePORTER application 10217025, 11 Solid Tumor Therapeutics Program (5P30CA091842-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10217025. Licensed CC0.

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