# Phenotyping and Biobanking Core

> **NIH NIH P50** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $578,727

## Abstract

PROJECT SUMMARY
The Center for Adolescent Rhythms, Reward, and Sleep (CARRS) Phenotyping and Biobanking Core (Core
B) supports the research projects through the acquisition of research subjects with specific phenotypic
characteristics required by the human and animal projects. Our central hypothesis is that late sleep timing,
short sleep duration, and circadian misalignment adversely impact cortico-limbic function in adolescents,
further enhancing reward sensitivity, impairing cognitive control, and increasing substance use risk. The
coordinated and deliberate procedures for assuring analogous phenotypic characteristics in humans and
animals provide the foundation for this translational scientific program. For human studies (Projects 1 and 2),
Core B will conduct systematic recruitment and screening of adolescents ages 13 through 15 years old to
provide participants systematically varied in sleep timing. For rodent studies, Core B will establish a breeding
and phenotyping pipeline to provide the animals required for Projects 3, 4 and 5. Core B will also provide
biobanking services, including the collection, management, and banking of specimens from adolescent
humans and adolescent HS rats to measure molecular rhythm phenotypes and to provide a high-quality
repository for future mechanistic studies. Core B contributes to this innovative translational research program
by collaboratively developing and implementing plans for assuring analogous phenotypes for CARRS human
adolescent and adolescent rodent model studies.

## Key facts

- **NIH application ID:** 10217068
- **Project number:** 5P50DA046346-02
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** DUNCAN B. CLARK
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $578,727
- **Award type:** 5
- **Project period:** 2020-07-15 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10217068

## Citation

> US National Institutes of Health, RePORTER application 10217068, Phenotyping and Biobanking Core (5P50DA046346-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10217068. Licensed CC0.

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