# CSHL 2020 Systems Biology Conference: Global Regulation of Gene Expression > **NIH NIH R13** · COLD SPRING HARBOR LABORATORY · 2021 · $29,774 ## Abstract Cold Spring Harbor Conference Systems Biology: Global Regulation of Gene Expression 2020 - 2024 ABSTRACT How cells control the expression of their genomes is a fundamental problem in biology. How the coordinate regulation of gene expression is affected by changes in the cellular and organismal environment is another fundamental question. Ever since the discovery that genes are encoded in the sequence of nucleotides that comprise the double strand DNA helix, there have been continuous investigations into these problems. The nuclear machineries that make transcripts as well as the many types of DNA sequences that serve to control gene expression have been discovered. Despite these efforts, many fundamental issues associated with the global regulation of gene expression remain unresolved. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined. We cannot yet predict a human gene's expression pattern with high accuracy from the sequence of its surrounding regulatory DNA or the pattern of nearby epigenetic marks, or how these are affected by environmental change. Nor, in the majority of cases, can we make rational alterations to the DNA that result in specific, predefined changes in expression. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problems of gene regulation. Thus we propose to host meetings that foster the free cross-disciplinary exchange of existing ideas and expertise. It is hoped that these meetings will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. This proposal seeks National Institutes of Health (NHGRI) funding primarily to support the active participation of young scientists (graduate students, postdoctoral fellows and new faculty) in a continuing series of scientific meetings on systems biology, which have previously been held at Cold Spring Harbor Laboratory (CSHL) and in Puerto Rico. The 2020-2024 conferences will be managed by CSHL on the CSHL campus. These meetings are intended to foster cross- disciplinary exchange of ideas and expertise between experimentalists and computational biologists interested in the organization and control of complex transcription networks in eukaryotes. The proposed meeting will focus on several key themes: Transcriptional Regulatory Networks; Cis-Regulatory Logic; Chromatin & Epigenetics; Post-transcriptional Regulation; Variation & Evolution; Emerging Technologies; Developmental Networks & Cellular Responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster session... ## Key facts - **NIH application ID:** 10217225 - **Project number:** 5R13HG010975-03 - **Recipient organization:** COLD SPRING HARBOR LABORATORY - **Principal Investigator:** DAVID J. STEWART - **Activity code:** R13 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $29,774 - **Award type:** 5 - **Project period:** 2019-09-10 → 2024-07-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10217225 ## Citation > US National Institutes of Health, RePORTER application 10217225, CSHL 2020 Systems Biology Conference: Global Regulation of Gene Expression (5R13HG010975-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10217225. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*