# Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)

> **NIH NIH U01** · BAYLOR COLLEGE OF MEDICINE · 2021 · $2,351,300

## Abstract

PROJECT SUMMARY
The proposed Baylor College of Medicine Mendelian Genomics Research Center (BCM-MGRC) builds on the
extensive discoveries and infrastructure established in the Baylor Hopkins Center for Mendelian Genomics.
This research program is nested within the Department of Molecular and Human Genetics at BCM and will
benefit from an extensive collaborative research infrastructure which includes, the Human Genome
Sequencing Center, the Undiagnosed Diseases Network Clinical Site, the Undiagnosed Diseases Network
Model Organism Screening Center, Baylor Genetics diagnostic laboratory, and the Baylor Knockout Mouse
Program. Notably, each of these programs has established their own national and international collaborations.
A phenotypically and ethnically diverse, international cohort of ~15,000 individuals and families with
challenging-to-diagnose rare disease conditions (those unsolved by routine clinical studies such as exome
sequencing) and who are re-contactable and consented for broad data-sharing will form the basis of the BCM-
MGRC research program. The Center will integrate novel methods of genomic data analysis, data sharing
across networks, implementation of newer genomic sequencing technologies, and methods for molecular and
organismal phenotypic interrogation of prioritized candidate disease genes and variants. The existing Data
Lake infrastructure will integrate with the Mendelian Genomics Data Coordinating Center (MGDCC) and AnVIL
to share key deliverables including genomic and phenotypic data, case metadata, and a BCM-MGRC-
developed Genomic Medicine Toolbox. As a fully integrated Mendelian Genomics Research Center, the BCM-
MGRC will inform development and delivery of an algorithm for solving the unsolved that will tackle complex
molecular mechanisms in the rare and common disease research space, with seamless integration of
anticipated discoveries to support clinical diagnostics and the generation of molecular floorplans from which to
develop precision therapeutics.

## Key facts

- **NIH application ID:** 10217746
- **Project number:** 1U01HG011758-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** RICHARD A GIBBS
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,351,300
- **Award type:** 1
- **Project period:** 2021-07-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10217746

## Citation

> US National Institutes of Health, RePORTER application 10217746, Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC) (1U01HG011758-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10217746. Licensed CC0.

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