# Central Hub for Kidney Precision Medicine - Administrative Core

> **NIH NIH U2C** · UNIVERSITY OF WASHINGTON · 2021 · $2,134,061

## Abstract

ABSTRACT
A major challenge for modern biomedical research has been the relative inability to translate the
increasing rate of scientific discovery into major therapeutic breakthroughs. This shortcoming has
been particularly dramatic in kidney diseases, where the number of randomized clinical trials
published in nephrology is fewer than all other specialties of internal medicine. Chronic kidney
disease (CKD) is a public health problem affecting more than 20 million people in the US, few drugs
other than inhibitors of the renin-angiotensin system have been proven to slow CKD progression,
lower mortality rates, or improve quality of life. Acute kidney injury (AKI) affects up to 10% of all
hospitalized patients in the US, and is associated with mortality, prolonged hospital length of stay,
and subsequent development or progression of CKD. Currently there is no accepted therapeutic
approach to either prevention or amelioration of the course of AKI There is a critical need to help
define CKD and AKI disease subgroups and identify critical cells, pathways and targets for novel
therapies. We propose to establish a multiscale understanding of CKD and AKI, by integrating
clinical data with the cell and organ level features of kidney disease progression including
interrogation of genomic and epigenomic drivers of disease. We plan to build the Kidney Precision
Medicine Project Central Hub on strong existing infrastructure led by a highly experienced,
multidisciplinary team with a strong track record of success. The overarching objective of the KPMP
Administrative Core is to facilitate successful interdisciplinary team science by fostering
communication, collaboration, and coordination among the KPMP Steering Committee (SC),
components of the Central Hub, Recruitment Sites, Tissue Interrogation Sites, EEP, OSMB, IRB
and sponsor. The overall goal of this team science is to promote scientific rigor and participant
safety in order to advance kidney precision medicine. As a key component of this model, the
Administrative Core will have primary responsibility for coordinating the operations of the KPMP,
establishing necessary working groups and relationships, forming and operating a Patient
Engagement Working Group, and administering an Opportunity Pool to form new partnerships. The
Administrative Core will additionally provide project management, budgeting, and fiscal
management for all Central Hub activities. The Administrative Core will be responsible for overall
day-to-day center operations, research, research training and education, and community outreach
activities, including information dissemination

## Key facts

- **NIH application ID:** 10218145
- **Project number:** 5U2CDK114886-05
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Jonathan Himmelfarb
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,134,061
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-09-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10218145

## Citation

> US National Institutes of Health, RePORTER application 10218145, Central Hub for Kidney Precision Medicine - Administrative Core (5U2CDK114886-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10218145. Licensed CC0.

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