# The biophysics and potential cell-type selectivity of acoustic neuromodulation

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $683,427

## Abstract

Summary
 Neuroscience has an essential requirement for large-scale perturbation tools. Such
tools would be transformative in the mapping of brain function, the causal testing of
neurotheoretic models, and the diagnosis and treatment of neurological disorders. The
proposed five-year project is aimed at uncovering the fundamental mechanisms of US
stimulation through the reciprocity of mathematical analysis, computational modeling and
experimental validation. Using a previously developed predicative model as a scaffold, we will
build a full explanatory theory of US stimulation effects in mice, including cell-type specific
effects of this perturbation modality. A large parameter space of US variables will be explored,
including spatiotemporal dynamics and duty cycle modulation, while sensitive two-photon
functional imaging metrics will be used to measure the biophysical impact of these parameters
on neural responses in the cortex, thalamus, and hippocampus in vivo.

## Key facts

- **NIH application ID:** 10218280
- **Project number:** 5R01NS109885-04
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Robert Crooks Froemke
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $683,427
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10218280

## Citation

> US National Institutes of Health, RePORTER application 10218280, The biophysics and potential cell-type selectivity of acoustic neuromodulation (5R01NS109885-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10218280. Licensed CC0.

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