# Biospecimen Core

> **NIH NIH P20** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2021 · $211,887

## Abstract

ABSTRACT
The Biospecimen Core of the COBRE, established by the Phase I of this COBRE, is to provide well-preserved
and properly annotated biospecimen such as tissue and blood components to the COBRE investigators and
other cancer researchers in the Stephenson Cancer Center of the University of Oklahoma. Data management
services of the core provides standardized annotations using a secure database system. The Core also supports
the investigators in the conception of prospective specimen collection protocols and specimen analysis to
minimize the effect of pre-analytic and analytic variables on study results. In conjunction with the Histology,
Immunochemistry, and Microscopy Core of the COBRE, histologic quality control will be ensured by board-
certified pathologists. In addition, the core provides tissue processing services including the preparation of
formalin-fixed paraffin-embedded (FFPE) and optimal cutting temperature (OCT) embedded tissue blocks
for subsequent histopathological analysis. To assist cancer researchers in carrying out high-throughput
molecular profiling studies in cancer, the core provides tissue microarray construction service. During the Phase
I COBRE funding period, 4 PJIs, 3 PPIs, and 69 non-COBRE investigators have used this core with resulting in
several grant applications and peer-reviewed publications. Under Phase II of this COBRE, the Biospecimen Core
will strive to continue its mission in providing high quality biospecimens to COBRE investigators as well as to the
greater community of cancer researchers in Oklahoma. This will be accomplished under three specific aims.
They are: 1. Provide annotated human biospecimens including tissues and blood components, 2. Aid in the
design and implementation of prospective specimen collection protocols, and 3. Construct tissue microarrays
tailored to individual and collaborative research projects.

## Key facts

- **NIH application ID:** 10219280
- **Project number:** 5P20GM103639-09
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Muralidharan Jayaraman
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $211,887
- **Award type:** 5
- **Project period:** 2012-09-05 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10219280

## Citation

> US National Institutes of Health, RePORTER application 10219280, Biospecimen Core (5P20GM103639-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10219280. Licensed CC0.

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