# Diabetic Animal Core

> **NIH NIH P30** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2021 · $296,000

## Abstract

PROJECT SUMMARY
 Diabetes represents a major threat to the health of the working population, and constitutes an immense
social and economic burden. Rodent models of streptozotocin (STZ)-induced or genetic diabetes are
commonly used in diabetes research. Diabetic animals have a high mortality rate and require intensive care
and characterization. Diabetic complications tend to occur only long after the onset of diabetes, and long-term
maintenance and monitoring of diabetic animals are labor-intensive and associated with high costs. The
objective of this Core is to centralize the induction, breeding, monitoring, maintenance, and use of diabetic
animal models, and to coordinate the sharing of diabetic animal tissues among the investigators.
 In the past nine years of this COBRE, the Diabetic Animal Core has provided service, diabetic animals,
and animal tissues to 35 investigators, including the COBRE Promising Junior Investigators (PJIs), members of
the Harold Hamm Diabetes Center (HHDC), and other diabetes researchers. This Core has provided support
to 208 publications and 29 funded NIH grants on campus. The Core has greatly increased the efficiency of
diabetes research using diabetic animal models and has reduced costs for PJIs and other diabetes
researchers at the HHDC. The Core has become an essential and unique facility for diabetes research in
Oklahoma. Considering the excellent service of this Core and rapid growth in diabetes research on our
campus, the HHDC started to provide funds to subsidize this Core in Phase II of our COBRE. The HHDC is
also committed to supporting the transition of this Core to an independent research core facility supported by
the HHDC after the completion of the COBRE Phase III. In Phase III, we will further improve the Core services
and start the transition of this Core to a HHDC-supported facility. In Phase III, we will induce diabetes by STZ
injection in rats and mice, and breed genetic diabetic animals as requested by investigators. We will also
monitor diabetes and collect “clinical data” on diabetic animals. We will coordinate sharing diabetic animal
tissues by different users and expand the diabetic animal tissue bank. Further, this Core will provide training or
technical assistance for specialized assays of diabetic complications. Through these efforts, this Core will
provide support for the Pilot Projects funded by the COBRE, greatly enhance diabetes research in Oklahoma
and contribute to further growth of the HHDC. It will also attract more local basic scientists into diabetes
research and facilitate recruitment of new diabetes researchers into Oklahoma. This Core will contribute to the
development of new treatments for diabetes and its complications.

## Key facts

- **NIH application ID:** 10219292
- **Project number:** 5P30GM122744-05
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Jian-Xing Jay Ma
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $296,000
- **Award type:** 5
- **Project period:** 2017-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10219292

## Citation

> US National Institutes of Health, RePORTER application 10219292, Diabetic Animal Core (5P30GM122744-05). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10219292. Licensed CC0.

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