# Domain-specific role of IL-17RA in controlling Klebsiella pneumoniae lung infection

> **NIH NIH R03** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $78,250

## Abstract

ABSTRACT
IL-17 is an essential mediator of immunity to Klebsiella pneumoniae (KP). Animal models lacking IL-17 signaling
or having IL-17 receptor (IL-17R) deficiency are susceptible to KP pneumonia. Although considerable research
effort has focused on how Th17 cells are generated and regulated, the mechanisms by which IL-17 and its
receptor IL-17R mediate specific downstream signals in relevant disease processes such as KP pneumonia are
not fully elucidated. Our efforts to understand KP pneumonia in mouse models revealed that the distal domain
of IL-17RA, also known as CBAD, is indispensable to control this infection. Thus, we propose to determine the
immune and molecular mechanisms by which the IL-17RA CBAD domain constrains KP pneumonia. We will
also perform parallel analyses to evaluate the cell-type-specific response by single-cell RNASeq. The findings
generated from this proposal will help us understand IL-17- dependent signaling mechanism by which KP
pneumonia can be controlled and to evaluate the lung immune response at a single cell resolution.

## Key facts

- **NIH application ID:** 10219359
- **Project number:** 5R03HL154231-02
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Giraldina Trevejo-Nunez
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $78,250
- **Award type:** 5
- **Project period:** 2020-07-20 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10219359

## Citation

> US National Institutes of Health, RePORTER application 10219359, Domain-specific role of IL-17RA in controlling Klebsiella pneumoniae lung infection (5R03HL154231-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10219359. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*