# Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)

> **NIH NIH UG1** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $165,540

## Abstract

ABSTRACT
Pain is one of the most common symptoms reported among cancer survivors, and yet it often remains
inadequately treated. Persistent and poorly managed pain is commonplace among cancer treatment survivors.
Treatment guidelines state patients should have access to pain coping skills training (PCST) interventions that
teach patients cognitive and behavioral coping skills to reduce pain and pain interference and enhance quality
of life. When delivered in-person, PCST can improve pain and functioning in people with cancer, and yet, these
interventions are underused in clinical care due to barriers such as high resource costs, shortage of trained
therapists, travel requirements, and costs of clinic visits. To address barriers, we developed a web-based PCST
program using an expert systems approach designed to retain therapeutically critical features of in-person PCST
that does not require therapist involvement. This program (painTRAINER) mimics in-person PCST via tailoring
algorithms and a knowledge database that applies our team’s specialized training and experience in delivering
PCST. The parent trial is evaluating whether painTRAINER is effective for self-management of cancer-related
persistent pain among cancer survivors who have completed treatment as compared to usual medical care. The
trial will be conducted at community sites across the country through the NCI’s National Community Oncology
Research Program (NCORP). IMPACTS is in its Year 1 (UG3) milestone-driven planning phase and in
preparation for transition to the trial implementation phase (UH3). The IMPACTS study entails a pragmatic,
randomized controlled clinical trial to determine whether painTRAINER plus usual care yields significant
improvements in pain severity and pain interference (Brief Pain Inventory) as well as in related symptom
outcomes from baseline to post-intervention for cancer survivors with persistent pain (as compared to usual care
alone). This administrative supplement requests funding to support initially unforeseen administrative and study
design modifications that developed during the UG3 phase of the IMPACTS trial and under the advisement of
NCI staff, including the following: 1) Provide additional funding to pay site accrual fees resulting from the
approved increase in sample size (from 438 to 456; n=18 additional participants) that was implemented to
account for changes in standard deviation estimates and effect sizes in power analyses (totaling $54,000); 2)
Provide additional funding to pay participant incentives resulting from the approved increase in sample size
(from 438 to 456; n=18 additional participants) (totaling $1,800), and 3) Provide additional funding to pay the
increase in the standard site accrual fees that has been implemented by NCORP in the time since the
IMPACTS study was funded (an increase of $500 per participant) for the originally proposed n = 438 sample of
participants (totaling $219,000).

## Key facts

- **NIH application ID:** 10219647
- **Project number:** 3UG1CA189824-07S2
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** DONALD BAIRD PENZIEN
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $165,540
- **Award type:** 3
- **Project period:** 2014-08-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10219647

## Citation

> US National Institutes of Health, RePORTER application 10219647, Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS) (3UG1CA189824-07S2). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10219647. Licensed CC0.

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