# Core D. Rodent Behavior Core

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $153,235

## Abstract

PROJECT SUMMARY – RODENT BEHAVIOR CORE
The present application seeks funding to continue the MIND Institute Intellectual and Developmental
Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013
and is the newest of the 14 IDDRCs in the network. The goal of the RBC is to support IDDRC projects using
translational rat and mouse models to advance understanding and treatment of the behavioral outcomes of
genetic, neuroanatomical, immunological, and environmental causes of IDDs. The RBC is designed to address
three specific aims. Aim 1 is to provide innovative, high quality, state-of-the-art behavioral testing of mice and
rats to enhance the quality and productivity of IDD research. The RBC will address this aim by offering a
comprehensive battery of neurobehavioral assays and related services, with tiers of service ranging from
consultation to full implementation of the study by RBC staff. Aim 2 is to provide learning opportunities for
trainees and faculty to become expert in rodent behavioral testing procedures, experimental design, and
accurate interpretation of data. This aim will be addressed by RBC staff offering involvement in the life cycle of
each study, from initial consultation in study design and selection of assays to hands-on training and supervision
in implementation of assays to consultation on data interpretation and input on manuscripts and grant
applications. Aim 3 is to contribute to the IDDRC network in disseminating best practices and standardizing
rodent behavioral testing protocols. This aim will be addressed by leveraging the internationally recognized
expertise of the RBC leadership in mouse and rat behavior assays to develop collaborations and consultations
with other IDDRC Rodent Cores; to participate in cross-IDDRC training of core personnel on novel, specialized
behavioral assays; and to validate standardized protocols for rodent behavioral assays. Infused in all activities
of the RBC as it addresses these aims is the imperative for rigor and reproducibility in preclinical research. The
RBC strives to ensure that all IDDRC studies include the necessary control assays, conduct two or more
corroborative assays within a behavioral domain, replicate findings in a second independent cohort, use breeding
strategies to obtain genotype controls, employ group sizes sufficient to achieve statistical power, and use males
and females to address sex as a biological variable. The Director of the RBC is Jacqueline Crawley, PhD.

## Key facts

- **NIH application ID:** 10220105
- **Project number:** 5P50HD103526-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Jacqueline N Crawley
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $153,235
- **Award type:** 5
- **Project period:** 2020-07-21 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10220105

## Citation

> US National Institutes of Health, RePORTER application 10220105, Core D. Rodent Behavior Core (5P50HD103526-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10220105. Licensed CC0.

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