# PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $2,156,809

## Abstract

Lower extremity peripheral artery disease (PAD) affects 10 million adults in the US and
increases the risk of mortality and leg amputation. Since it has broad implications for quality of
life and maintenance of independent living, the impact of PAD on physical activity and function
is of great interest. To characterize the impact of PAD on free-living daily physical activity and
examine the value of objective assessment of daily physical activity for PAD management,
diagnosis and risk stratification, we propose to evaluate enrollees of the Hispanic Community
Cohort Study/Study of Latinos (HCHS/SOL). Participants who were originally studied during
2008-2011 will complete a return in person visit during 2019-2021. Through comprehensive
clinical assessment of lower extremity blood vessels, multi-day accelerometry and physical
function testing, we address the hypothesis that PAD will be identifiable by suboptimal usual
activity patterns including longer sedentary time, higher activity fragmentation and diurnal
patterns of activity. The study will also determine the prognostic value of 7-day physical activity,
above and beyond self-reported leg symptoms and clinic-based physical function, to predict
PAD-associated major health outcomes. Finally, duplex ultrasound of leg arteries in
combination with other study assessments will be used to better resolve the population with
indeterminant results on peripheral arterial disease clinical test. Results will help to guide the
application of both clinical screening protocols and mobile technologies to identify, predict and
intervene upon major health sequalae associated with PAD.

## Key facts

- **NIH application ID:** 10220120
- **Project number:** 5R01HL146132-03
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Robert C Kaplan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,156,809
- **Award type:** 5
- **Project period:** 2019-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10220120

## Citation

> US National Institutes of Health, RePORTER application 10220120, PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of Latinos (5R01HL146132-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10220120. Licensed CC0.

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