# Nonhuman Primate Core

> **NIH NIH P01** · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $248,262

## Abstract

NHP Core - Project Summary/Abstract
The emergence of Zika virus (ZIKV) in the Americas and its association with fetal demise and birth
defects represents a significant public health challenge. To date, very little is known about how maternal-fetal transmission occurs and what factors influence fetal pathology during congenital infection.
Thus, understanding the pathophysiology of ZIKV infection during pregnancy is critical. The use of a
nonhuman primate (NHP) model for ZIKV infection during pregnancy will allow finescale and comprehensive examination of the pathology and duration of infection, the influence of pre-existing dengue virus
immunity on infection, and the immune response to infection; important studies that are not possible in
humans. The NHP model is additionally ideal for these studies due to the relative similarity of macaque
pregnancies to human pregnancies. The Non-Human Primate (NHP) Core is an integral component of
the Program Project and provides direct support to all three Projects. The NHP Core will provide healthy
animals, coordinate and implement all aspects of the proposed NHP experiments, establish and verify
pregnancies and monitor maternal and fetal health, perform necropsies and detailed histopathological
examinations, assess neonatal outcomes, and provide compliance oversight and biosafety training for
all three Projects.

## Key facts

- **NIH application ID:** 10220701
- **Project number:** 5P01AI132132-04
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Saverio Vincent Capuano
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $248,262
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10220701

## Citation

> US National Institutes of Health, RePORTER application 10220701, Nonhuman Primate Core (5P01AI132132-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10220701. Licensed CC0.

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