# Exposure to PFNA and other PFAS in drinking water and associations with health-related outcomes in Gloucester County NJ

> **NIH ALLCDC U01** · RBHS-SCHOOL OF PUBLIC HEALTH · 2021 · $1,000,000

## Abstract

PROJECT SUMMARY
The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the need for additional
epidemiological research on the health effects of poly- and perfluoroalkyl substances (PFAS) exposures,
particularly from contaminated drinking water and for compounds even less studied than perfluorooctanoic acid
(PFOA) and perfluorooctane sulfonic acid (PFOS), such as perfluorononanoic acid (PFNA). The highest levels
of PFNA contamination in public and private water wells recorded anywhere in the world were found in
Paulsboro and West Deptford New Jersey, where measurable levels of other poly- and perfluoroalkyl
substances (PFAS) were also detected. Contaminated drinking water is an important and growing source of
exposure to PFNA and other PFAS, and it estimated that millions of adults and children are exposed to PFAS
in drinking water. Associations between serum PFAS levels in the general population and a wide range of
health effects have been reported, but relatively little is known about health effects from consuming water
contaminated with PFAS. There is a critical need to better understand the health hazards and risks of PFNA
and other PFAS in drinking water. The main objective of this proposal is to evaluate associations between
health outcomes and multiple estimates of exposure to PFNA and other PFAS among members of these
communities and the other study sites in a multi-site study. A number of hypotheses will be tested, including
that exposure to PFNA and other PFAS are associated with blood lipid levels, renal function and kidney
disease, thyroid hormones and disease, liver function and disease, glycemic parameters and diabetes, and
immune response and function in both children and adults. Additional hypothesized effects to be studied
include differences in sex hormones and sexual maturation, vaccine response, and neurobehavioral outcomes
in children, as well as cardiovascular disease, osteoarthritis and osteoporosis, endometriosis, and autoimmune
disease in adults. The rationale for these multiple cross-sectional analyses is to test hypotheses for which
there is sufficient statistical power based on prior reports, to develop new hypotheses, and to build a
foundation for future knowledge generation with members of these communities. As part of the multi-site study
with a target enrollment of 6,000 adults and 2000 children, 1,000 adults and 350 children from the Paulsboro
and West Deptford municipalities who consumed water from wells contaminated with PFNA and other PFAS
will be enrolled. Assessment of exposure to PFAS will be based on blood concentrations of PFAS and drinking
water exposure reconstruction and PBPK modeling of internal exposure, including development of novel
models for PFNA. Estimation of associations between health outcomes and measured and modeled exposure
to PFAS will be done for this site and across sites of this multi-site study. The proposed project is relevant to
public health, because our results...

## Key facts

- **NIH application ID:** 10220742
- **Project number:** 5U01TS000304-03
- **Recipient organization:** RBHS-SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** ROBERT John LAUMBACH
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2021
- **Award amount:** $1,000,000
- **Award type:** 5
- **Project period:** 2019-09-30 → 2024-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10220742

## Citation

> US National Institutes of Health, RePORTER application 10220742, Exposure to PFNA and other PFAS in drinking water and associations with health-related outcomes in Gloucester County NJ (5U01TS000304-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10220742. Licensed CC0.

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