# Quantitative Methods Research Project

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $482,516

## Abstract

Project 3 - QUANTITATIVE METHODS RESEARCH PROJECT - Abstract
Over the past three decades, there have been great advances in HIV research, especially in diagnostics
and treatment. Curing HIV will require further advances, particularly in the development of new agents and
methods for evaluating incremental improvements in their contribution to cure.
Our proposed Revealing Reservoirs during Rebound (R3) program will use a large battery of new
technologies to investigate how HIV persists in and populates reservoirs throughout the body. Such new
insights will be crucial in developing strategies aimed at curing HIV. To make maximal use of existing and
newly generated data requires parallel advances in quantitative methods; hence, we propose a
Quantitative Methods Research Project (RP). This RP will maximize the utility of data and samples
collected in the overall program through the development of novel approaches for their analysis. The aims
of our Quantitative Methods RP include:
Aim 1: Discover biomarkers that can predict viral rebound when antiretroviral therapy (ART) is stopped to
help guide future curative strategies.
Aim 2: Precisely characterize HIV populations in T cell subsets and throughout the body and the impact of
treatment interruption and re-initiation on these viral populations.
Aim 3: Determine immune mechanisms by which HIV populations persist during ART by measuring
biological quantities associated with viral rebound dynamics after stopping ART, and HIV population
dynamics in cellular subsets and anatomic compartments.
Aim 4: Create a global host model that uses mechanistic and empiric modeling methods to integrate our
observations from viral rebound dynamics, HIV population of T cell subsets and tissues, and immunologic
and virologic quantities to better understand the HIV in the body and the factors that sustain HIV
persistence during ART and contribute to viral rebound when ART is stopped.
The successful completion of these aims will provide the analytical framework to better understand the
mechanistic underpinning of how HIV persists in the setting of ART, and what factors may be attractive
targets to disrupt this viral persistence.

## Key facts

- **NIH application ID:** 10223145
- **Project number:** 5P01AI131385-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** VICTOR GERARD DEGRUTTOLA
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $482,516
- **Award type:** 5
- **Project period:** 2017-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10223145

## Citation

> US National Institutes of Health, RePORTER application 10223145, Quantitative Methods Research Project (5P01AI131385-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10223145. Licensed CC0.

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