# PDX Core

> **NIH NIH U54** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $34,227

## Abstract

PDX CORE PROJECT SUMMARY 
The goals of the patient-derived xenograft (PDX) Development and Trial Center (PDTC) PDX Core are to 
establish and maintain PDX lines for the purpose of conducting animal preclinical trials using experimental and 
standard-of-care therapeutics; to promote quality-control, reproducibility, and collaboration by developing and 
maintaining shared Standard Operating Procedures (SOPs) for PDX development, maintenance, 
experimentation, and pathogen testing; to provide infrastructure to manage large PDX collections and to 
generate, store, and manage PDX-based experimental data generated by the projects; to facilitate exchange of 
PDX models between the PDXNet program; and to facilitate transfer of experimental data to the PDTC 
Biostatistics and Bioinformatics Core and the PDTC PDXNet Data Commons and Coordinating Center to relate 
treatment responses to the molecular characteristics of individual patients’ tumors. Our PDTC PDX Core current 
comprises 162 breast PDX lines available for projects within our PDTC Center and across the PDXNet program.

## Key facts

- **NIH application ID:** 10223226
- **Project number:** 5U54CA224076-04
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Alana L. Welm
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $34,227
- **Award type:** 5
- **Project period:** 2017-09-25 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10223226

## Citation

> US National Institutes of Health, RePORTER application 10223226, PDX Core (5U54CA224076-04). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10223226. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*