# Beyond Odor Receptors: Molecular basis of insect olfaction

> **NIH NIH R35** · UNIVERSITY OF CONNECTICUT STORRS · 2021 · $402,500

## Abstract

Complex organisms such as vertebrates and insects have developed specialized chemosensory organs in order
to locate food, evaluate mates, and avoid toxins. The sensing of volatile odors is particularly challenging because
odors are often present at low levels in turbulent plumes, yet many animal behaviors rely on the faithful coding
of odor signals by olfactory receptor neurons. The past few decades have witnessed an explosion of research
into olfactory systems, following the cloning of the first odor receptors. Initial research focused on understanding
odor receptor function, characterizing their odor response profiles, and understanding their effects on behavior.
However, many open questions remain regarding the molecular and cellular mechanisms supporting olfaction in
the periphery, particularly in regards to insect olfaction. What signaling mechanisms are downstream of insect
odor receptor activation? How are odors removed from the peri-neuronal space? What contribution do non-
neuronal support cells make to olfactory neuron activity? How are the support cells of olfactory sensilla similar
or different than those in sensilla that mediate other sensory modalities? My lab seeks answers for these
questions in the Drosophila antenna, their primary olfactory organ. This versatile model organism is
advantageous for such studies because we can exploit the large number of available genetic tools and existing
knowledge on its stereotyped receptor and neuronal organization.
Here we propose to study the functions of several candidate genes that have arisen from our recent
computational screen, and may provide answers to several outstanding questions in field olfaction field as
described above. One project centers on several highly conserved antennal-enriched signaling genes and their
putative roles in amplification and desensitization downstream of odor receptor activation. Two additional
projects focus on the interactions between non-neuronal support cells and the signaling of olfactory neurons.
One investigates the role of support cells in odor degradation using candidate metabolic genes that arose from
our screen and an RNASeq-based method to identify new candidates. We will also elucidate the potential
differences in function between the major support cell classes, which are found not only in olfactory sensilla but
also in sensilla that mediate other physiological functions.

## Key facts

- **NIH application ID:** 10223371
- **Project number:** 5R35GM133209-03
- **Recipient organization:** UNIVERSITY OF CONNECTICUT STORRS
- **Principal Investigator:** Karen Anne Menuz
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $402,500
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10223371

## Citation

> US National Institutes of Health, RePORTER application 10223371, Beyond Odor Receptors: Molecular basis of insect olfaction (5R35GM133209-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10223371. Licensed CC0.

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