Administrative Core Abstract Since its establishment in 1975 as a non-profit organization, the Inter Tribal Council of Arizona, Inc. (ITCA) has advocated for self-determination for its Member Tribes through public policy development, research, and education. The membership of ITCA is comprised of leaders from 21 federally recognized tribes in Arizona. ITCA operates more than 30 projects and employs a staff of 70 to provide technical assistance and training to tribal governments in program planning and development, research and data collection, resource development, education, health, management and evaluation. Strengthening tribal governance is at the core mission of ITCA including taking action on matters that affect Member Tribes individually or collectively and promoting tribal sovereignty. The University of Arizona and the Inter Tribal Council of Arizona boasts a successful 20-year partnership through the NARCH program in the American Indian Research Center for Health (AIRCH). Our application for the Native American Research Center for Health XI (NARCH XI) focuses on improving health disparities in our Tribes by strengthening tribal governance through research. We propose four projects: 1. A capacity building project to develop the Arizona Tribal Research Review Board at ITCA to serve tribes in Arizona who do not have the resources to establish their own review process; 2. A graduate student career enhancement program to train an AIAN data science workforce intimately knowledgeable about AIAN health issues and medical and public health informatics; 3. A pilot project to understand environmental endocrine disruption, metal and antibiotic resistance in bacteria, and wastewater epidemiology; and 4. A research project to elucidate the links between governance, health care, the environment and community wellness. The Administrative Core is critical to the success of the Center. It provides administrative, fiscal and management oversight of all components and projects and guidance in evaluation and planning. Process is key to the success of the Center and the Administrative Core provides the resources to keep all elements of the Center functioning and moving forward and serves as a catalyst to engage all the partners in regular and culturally respectful communication and relationship building.