# Core C  Analysis and Modeling --Davenport UNSW

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2021 · $174,220

## Abstract

The Analysis and Modeling Core will support the Program by 1) developing optimal study design and
modeling methods for measuring and comparing S(H)IV reactivation from latency in monkeys treated with
bNAbs or FTY-720; 2) developing analytical approaches for identifying early sources of SIV reactivation and
quantification of reservoir ‘re-seeding’ following analytical treatment interruption (ATI); 3) analyzing immune
dynamics and viral selection during ATI and rebound; and 4) coordinating and integrating analysis between
Projects 1 & 2, and providing data and analysis tools to the broader research community. The AMC will be
integrated closely within all projects and sub-projects to ensure that the experimental and animal research is
designed and conducted to maximize our ability to dissect the dynamics of viral reactivation and the impact of
antibodies and cell migration on this. Members of the AMC will work closely with the Project leaders to
develop optimal study designs, including parameters such as sampling times and depth of sequencing
required.

## Key facts

- **NIH application ID:** 10224006
- **Project number:** 5P01AI131338-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Miles Philip Davenport
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $174,220
- **Award type:** 5
- **Project period:** 2017-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10224006

## Citation

> US National Institutes of Health, RePORTER application 10224006, Core C  Analysis and Modeling --Davenport UNSW (5P01AI131338-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10224006. Licensed CC0.

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