# Pathogenesis of Rebound SIV/HIV Viremia After Antiretroviral Therapy

> **NIH NIH P01** · NORTHWESTERN UNIVERSITY · 2021 · $59,263

## Abstract

Project Summary
The purpose of this administrative core is to support high levels of innovation and collaboration, implement
research team processes, and assume responsibility for administrative work as the foundational infrastructure
enabling the investigators to focus on achieving the scientific goals of this program project, "Pathogenesis of
Rebound SIV/HIV Viremia after Antiretroviral Therapy". Progress toward the ultimate goal of eliminating
rebound of HIV viremia after stopping early antiretroviral therapy will be accelerated if the experimental
strategies of this PPG are informed and actively updated of discoveries from the entire, international HIV
research effort. We have proposed creative and feasible mechanisms to assure the active engagement of our
entire PPG team with new knowledge and to support nimble re-design of experimental plans with appropriate
allocation of resources. The design of the AC uses robust tools for communications and administrative
processes with the intent to be economically efficient and reserve resources for experimentation in the
scientific projects and non-human primate core. The AC will be led by the PPG Program Director, Dr. Richard
D'Aquila, and will address the following three aims: 1) Establish governance structures facilitating maximum
research collaboration and productivity, implement processes for effective communications, and promote
excellence via critical, productive external review, 2) Assure that PPG investigators function at the edge of
discovery by supporting continual evolution of experimental strategy informed by engagement with HIV
research advances outside the PPG, and 3) Establish efficient processes for administrative and fiscal
management of PPG resources and effort across all performance sites. The AC will use an experienced
Program Manager, an Executive Committee of the principal investigators, and an annually-convened Scientific
Advisory Board to manage, govern, and review the PPG, respectively. The AC will work with an additional,
innovative component to keep PPG research at the edge of discovery - the CORA (Clinical Observation of
Rebound after pausing ART) Advisory Team. The CORA Advisory Team (CAT) will bring together leaders
from the US Military HIV Research Program investigating early infection in a human cohort in Thailand (the RV
254/SEARCH 010 study), clinicians and clinical investigators from diverse Chicago institutions at the forefront
of HIV care, and patients in order to review the newest information in HIV cure and viremia rebound research
and plan a human pilot, observational study in years 4-5 of this PPG. AC support of the PPG scientific team
and the CAT will accelerate the pace of scientific discovery by strengthening integration, promoting
communications, efficiently delivering administrative services, and lowering organizational barriers to allow
investigators to productively and interactively advance the scientific aims of this program.

## Key facts

- **NIH application ID:** 10224630
- **Project number:** 5P01AI131346-05
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Richard D'Aquila
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $59,263
- **Award type:** 5
- **Project period:** 2017-07-05 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10224630

## Citation

> US National Institutes of Health, RePORTER application 10224630, Pathogenesis of Rebound SIV/HIV Viremia After Antiretroviral Therapy (5P01AI131346-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10224630. Licensed CC0.

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