# Data Management and Statistical Core

> **NIH NIH U54** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $56,863

## Abstract

PROJECT SUMMARY - DATA MANAGEMENT AND STATISTICAL CORE (DMSC)
The Data Management and Statistical Core (DMSC) will provide effective statistical planning and data
management support to optimize the successful accomplishment of the scientific aims of the Cervical Cancer
Prevention Partnership (C2P2) Center in Peru and the Dominican Republic. The DMSC will support the
proposed Clinical Trials Program that will span the continuum of cervical cancer prevention from vaccination
through treatment. The clinical trials will use a new combination of prevention and treatment methods aimed at
point-of-care and low-infrastructure support to address the burden of HPV-related cancers in HIV-infected
persons in low-resource settings. The ultimate intent of these trials is to advance the field toward the
elimination of cervical cancer among vulnerable populations with HIV. Trial 1 will identify new dosing schedules
to improve the immunogenicity of HPV vaccination among children living with HIV (CLWH). Trial 2 will
ascertain the contribution of new technologies to refine algorithms for screening and triage of women living with
HIV (WLWH). Trial 3 will assess non-surgical immune-based treatments of precancerous lesions to interrupt
progression to cervical cancer in WLWH. In Aim 1, the DMSC will provide design and analysis support for the
three clinical trials; in Aim 2 the DMSC will provide secure data management and safety monitoring services;
and in Aim 3 the DMSC will advance the mission of the science through the application of innovative statistical
analysis and methods. The DMSC leader Dr. Chen will collaborate closely with the Partnership Center’s
scientific leadership in the Administrative and Coordinating Core and Clinical Trial Co-Chairs to develop
efficient and high-quality trials that will impact the prevention of cervical cancer in the Latin America/Caribbean
region.

## Key facts

- **NIH application ID:** 10224784
- **Project number:** 5U54CA242977-03
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** Ying Qing Chen
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $56,863
- **Award type:** 5
- **Project period:** 2019-09-18 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10224784

## Citation

> US National Institutes of Health, RePORTER application 10224784, Data Management and Statistical Core (5U54CA242977-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10224784. Licensed CC0.

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