# NeMO Archive: SCORCH Support, Coordination and Outreach

> **NIH NIH UM1** · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $1,381,776

## Abstract

SUMMARY
We propose to set up a data coordination center to analyze single cell and other molecular data sets generated
by Single Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance
use disorder projects. This project will leverage our Neuroscience Multi-Omic Data Archive which will host most
of the BRAIN initiative multi-omic data (NeMO Archive; R24MH114788) and represents several key existing
resources for data management, integration and web presentation tools developed by the University of
Maryland group. The Principle Investigator, Co-investigators, and staff of this project have diverse expertise
required to marshall data across the SCORCH project consortium, including experience in data collection from
multiple institutions, large-scale quality control and analysis processing capability, familiarity with NIH policy,
and direct experience with public archive deposition strategies. Activities will be organized around the NeMO
Archive, a data repository that is specifically focused on the storage and dissemination of `omic data from the
BRAIN Initiative and related brain research projects. We will utilize a federated model for data storage such
that the physical location of data can be distributed between the NeMO local file system, public repositories,
and the Broad cloud computing environment. The NeMO-SCORCH data center will be fully consistent with the
principles advanced by research community members who are launching resources in next generation NIH
data ecosystem. These practices include FAIR Principles, documentation of APIs, data-indexing systems,
workflow sharing, use of shareable software pipelines, and centralized storage on cloud-based systems. The
information incorporating into the NeMO-SCORCH data center will, in part, enable understanding of 1)
genomic regions associated with brain abnormalities and disease; 2) transcription factor binding sites and
other regulatory elements; 3) transcription activity; 4) levels of cytosine modification; and 5) histone
modification profiles and chromatin accessibility.

## Key facts

- **NIH application ID:** 10224944
- **Project number:** 5UM1DA052244-02
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** TIMOTHY L TICKLE
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,381,776
- **Award type:** 5
- **Project period:** 2020-08-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10224944

## Citation

> US National Institutes of Health, RePORTER application 10224944, NeMO Archive: SCORCH Support, Coordination and Outreach (5UM1DA052244-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10224944. Licensed CC0.

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