# Core 1: Biospecimen and Pathology Core

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $174,226

## Abstract

Core 1: Biospecimen and Pathology Core (BiPC) 
SUMMARY/ABSTRACT 
The Biospecimen and Pathology Core (BiPC, Core 1), a biorepository and multi-faceted research resource led 
by experienced neuropathologists and cell biologists with ongoing active research expertise, will provide critical 
support for the translational prognostic, diagnostic, and therapeutic studies proposed in the UCLA SPORE in 
Brain Cancer. Working closely with the Biostatistics, Bioinformatics, and Data Management Core (BBD, Core 
3), BiPC will maximize optimal biospecimen collection/storage and efficient disbursement of consented, 
clinically annotated, and molecularly characterized biospecimens. This Core will support all four SPORE 
projects with 24/7 tissue procurement, clinical and family history annotation, and molecular characterization of 
tissues, plus research support in gliomasphere/neurosphere cultures, tissue microarray, and patient-derived 
orthotopic xenografts (PDOX). The Biospecimen and Pathology Core Co-Directors and Investigators have a 
long collaboration history with each other and with all the SPORE Project Leaders, as shown in joint 
publications, grants, and consortia. In addition to an excellent program for the collection, processing, storage, 
and dissemination of important biospecimens in support of the proposed SPORE research projects, the BiPC 
agenda goes well beyond these core functions to the innovative development of new scientific approaches for 
the maximization of rare/sparse specimen collection and the development of new animal models for 
therapeutic drug discovery. As part of this core, brain cancer cells grown in animals will be specially adapted 
to have a fluorescent label so that growth or shrinkage of the tumor can be serially followed in vivo when 
experimental treatments are given to the animals. The BiPC will develop and provide these materials, 
resources, and information to SPORE investigators and others, both inside and outside of UCLA. An 
outstanding team of experienced, accomplished, determined, and productive investigators has been 
assembled for this Biospecimen and Pathology Core. It also has strong institutional commitment in an excellent 
collaborative environment, which will help to ensure the success of the overall goals of this SPORE proposal.

## Key facts

- **NIH application ID:** 10225546
- **Project number:** 5P50CA211015-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** FAUSTO Rodriguez
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $174,226
- **Award type:** 5
- **Project period:** 2017-08-11 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10225546

## Citation

> US National Institutes of Health, RePORTER application 10225546, Core 1: Biospecimen and Pathology Core (5P50CA211015-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10225546. Licensed CC0.

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