# A multilevel intervention to support weight loss among individuals with prediabetes in primary care settings

> **NIH NIH K23** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $192,871

## Abstract

PROJECT SUMMARY / ABSTRACT
Candidate: Dina H. Griauzde, MD, MSc is a general internist and early career health services researcher
focused on preventing type 2 diabetes (T2DM). Dr. Griauzde’s long-term career objective is to become an
independent physician-scientist leading the development and evaluation of tailored, multilevel interventions for
T2DM prevention that can be scaled and sustained within diverse practice settings.
Research Context: Weight loss is the key driver of T2DM risk reduction. Patients prefer and benefit from
preference-sensitive weight loss treatment plans, which may require adaptations over time to optimize
outcomes. While primary care providers and practices theoretically play a central role in supporting patients’
weight loss, they lack coordinated, effective, and sustainable strategies to personalize and adapt treatment
plans to help more individuals with prediabetes achieve clinically significant weight loss. Accordingly, obesity
remains poorly managed in primary care settings.
Specific Aims: The overarching aim of this proposal is to use implementation science (i.e., the study of
provider behavior within the context of organizational constraints) to develop and pilot test a novel multilevel
intervention to support personalized and adaptable weight loss treatment plans in primary care settings.
Multilevel interventions target at least two levels of influence (e.g., providers, health system) and are a
promising strategy to promote significant and sustained changes in clinical practice. Intervention components
will be selected to address key determinants of successfully supporting patients’ weight loss.
Research Plan: Dr. Griauzde will use a theory-based implementation science checklist to guide semi-
structured interviews with patients, providers, practice staff, and system leaders to identify determinants of
successfully supporting patients’ weight loss (Aim 1). She will then link key determinants to evidence- and
theory-based implementation strategies to develop of a novel, multilevel intervention, Support to Prevent T2DM
(StoP DM), consisting of (1) personalized weight loss plans; (2) remote weight monitoring; and (3) proactive
outreach by primary care teams and/or automated tools to provide support and/or adapt treatment plans to
optimize weight loss (Aim 2). She will pilot test the intervention and conduct a mixed methods evaluation (Aim
3). These data will inform a future multisite study of the refined intervention.
Career Development Plan: Dr. Griauzde will develop expertise in (1) implementation science; (2) multilevel
intervention design; and (3) mixed methods design and evaluation of clinical trials. Dr. Griauzde’s training will
be supported by highly experienced, interdisciplinary mentors; advanced didactic coursework; and participation
in research and career development meetings and seminars within an ideal training environment. This award
will enable Dr. Griauzde to become an independent investigator and nat...

## Key facts

- **NIH application ID:** 10225629
- **Project number:** 5K23DK123416-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Dina Hafez Griauzde
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $192,871
- **Award type:** 5
- **Project period:** 2020-08-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10225629

## Citation

> US National Institutes of Health, RePORTER application 10225629, A multilevel intervention to support weight loss among individuals with prediabetes in primary care settings (5K23DK123416-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10225629. Licensed CC0.

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