Project Summary / Abstract The conduct of clinical research is essential to improving the treatment options of cancer patients. Many treatment protocols are complex and prescribed using electronic health record systems where the treatment protocol orders have been built previously. The work of building these treatment protocols is a complex process involving many steps, substantial time, and can be the limiting step in opening clinical trials. Multi-arm and protocol amendments can be particularly time consuming to build. Unfortunately for multi-site clinical trials, this build process is duplicated at each site representing a lack of efficiency in the overall clinical research system. This project seeks to bring together a consortium of NCI-designated cancer centers who are leaders in both the conduct of clinical research and in clinical informatics, along with coordination with EHR companies, to establish standardized build conventions, develop means to make clinical trial protocol builds interoperable across sites, and ultimately to make the conduct of clinical research substantially more efficient. In this way we will be able to better leverage the power of clinical informatics systems to accelerate the conduct of clinical cancer research.