# Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical Center

> **NIH NIH U01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $59,442

## Abstract

MOST Administrative Supplement
Grant U01AG018947 (Lewis)
PROJECT SUMMARY
Knee osteoarthritis (OA) is a common chronic painful disorder that is the most frequent cause of mobility
disability in older people. The MOST study has been a major source of new knowledge about the course of this
disease and factors that affect its course. Since the study began in 2003, it is increasingly recognized that by
the time people develop chronic symptoms of knee OA, they usually have advanced structural findings of
disease on MRI. Findings such as meniscal tears, malalignment and cartilage loss drive further structural
deterioration and almost certainly limit prevention opportunities. We believe that prevention opportunities are
likely to be greater if started in those who do not yet have severe continuous knee pain or advanced structural
findings of disease.
The functional impacts of knee OA occur in older people who experience multiple musculoskeletal
comorbidities, and preventing disablement from OA requires a broader perspective than a focus on a single
knee. For example, those with pain in one knee are at high risk of pain in other lower extremity musculoskeletal
regions and, even if the knee is replaced, they may ultimately need treatment for pain in other joints developing
as a consequence of the first joint affected. Also, in addition to functional loss, persons with OA experience
buckling, falls and constraints in their involvement with the outside environment.
We suggest there are opportunities to develop treatments and disease prevention strategies that have been
unexplored and that by using new technologies and focusing on persons at a milder or earlier disease stage
than previous studies, we can identify such opportunities. We propose to recruit a new mild disease cohort and
continue to study the existing MOST cohort to identify new risk factors for disease and to study consequences
of disease. Our goal is to find new strategies to prevent disease at an early stage and to limit the impact of
disease once it has occurred.

## Key facts

- **NIH application ID:** 10225905
- **Project number:** 3U01AG018947-18S1
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Cora E Lewis
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $59,442
- **Award type:** 3
- **Project period:** 2001-01-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10225905

## Citation

> US National Institutes of Health, RePORTER application 10225905, Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical Center (3U01AG018947-18S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10225905. Licensed CC0.

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