# Core 2: Clinical and Tissue Core

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2021 · $169,732

## Abstract

Project Summary (Core 2)
Modern biomedical research is being transformed by what is increasingly becoming a flood of information.
Electronic medical records have opened unprecedented opportunities for studies investigating a wide range of
problems ranging from epidemiological aspects of human disease to the comparative effectiveness of various
treatment protocols. Similarly, genomic technologies such as next-generation DNA and RNA sequencing have
opened a floodgate of data and information that promises to shed light on the complex nature of human
disease. In this information-rich age, one of the greatest challenges is therefore no longer generating data, but
effectively integrating it so that it can be used to advantage. Because clinical practice has long been separate
from the research enterprise at most academic health centers, a situation has evolved in which clinical and
research data exist in separate, often incompatible domains with a variety of technical, institutional, and
organizational barriers between them. Further limiting our ability to extract the maximal value of the data we
have available is the fact that data within institutions is rarely integrated with the vast body of data available in
the public domain. Similarly, another need is to aid Investigators better characterize and identify tumor biologic
and molecular genetic correlates for response, progression, and survival by collecting, preserving and
distributing tissue derived from patients on clinical protocol. A large sources of clinical data will be used in this
program project. The data for this large IFM/DFCI collaborative clinical trials (1260 MM patients, following
induction HDT and consolidation, achieving minimal residual disease will be randomized to lenalidomide with
or without daratumumab) are collected in an established clinical trials database at the IFM and DFCI. The aims
of Core B are to create, maintain, and quality control the clinical database (Specific Aim 1); to collect,
transport, process and store tissue samples from all sites utilizing standardized procedures in centralized
tissue banks (Specific Aim 2); and to develop an integrated database to integrate the sample tracking and
oncogenomic information with the relevant clinical data from the clinical trials database with web based query
capabilities (Specific Aim 3).

## Key facts

- **NIH application ID:** 10226187
- **Project number:** 5P01CA155258-10
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** herve Avet loiseau
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $169,732
- **Award type:** 5
- **Project period:** 2011-12-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10226187

## Citation

> US National Institutes of Health, RePORTER application 10226187, Core 2: Clinical and Tissue Core (5P01CA155258-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10226187. Licensed CC0.

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