# Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort Study

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $59,522

## Abstract

Abstract
According to the 2014 U.S. National Health Interview Survey, 5.5% of adults aged 18-39 years old self-
reported trouble with hearing without a hearing aid. Among adults 40-69 years of age, the rate was 19%
increasing to 43% among adults aged 70 and over with 63% reporting mild hearing loss. To date, there has
been no published results from these survey data of people living with HIV (PLWH) due to lack of reported HIV
status. In a pilot study of middle-aged and aging HIV positive and HIV seronegative men and women
conducted in Washington DC and Baltimore, HIV infection was associated with low and high frequency hearing
loss. But, more rigorous studies are needed, especially as more than half of PLWH in the U.S. are over the age
of 50 years old. Besides age and race/ethnicity differences in hearing and balance, being overweight,
increased alcohol consumption, smoking, less physical activity, the occurrence of hypertension and diabetes
are common risk factors for hearing and balance problems. These risk factors may also be higher in PLWH
and share a common hallmark of inflammation and immune activation. Furthermore, hearing and balance
problems may contribute to neurocognitive and physical dysfunction, which are also of concern in aging
PLWH. Finally, there is no research on the use of hearing testing applications in adults with HIV. Evaluation of
the feasibility of using a hearing testing application and the accuracy of a smartphone hearing testing
application in PLWH and their HIV seronegative counterparts are needed. We propose to address these gaps
in knowledge by implementing cohort-wide administration of the NHANES hearing (and balance questionnaire)
in the MACS-WIHS Combined Cohort Study (MWCCS) in approximately 4,100 active middle aged and aging
men and women living with and without HIV. In a subset of participants from the Washington-DC and Baltimore
sites with baseline hearing and balance data collected in 2009-2010 with follow-up testing in 2020-2021, we
propose to investigate whether the trajectory of markers of immune activation and inflammation contribute to
progression of hearing and balance issues, and whether a smartphone hearing test application may be a
feasible method to capture hearing trouble in PLWH compared to HIV seronegative participants.

## Key facts

- **NIH application ID:** 10226754
- **Project number:** 3U01HL146333-02S2
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Roger Detels
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $59,522
- **Award type:** 3
- **Project period:** 2019-04-15 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10226754

## Citation

> US National Institutes of Health, RePORTER application 10226754, Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort Study (3U01HL146333-02S2). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10226754. Licensed CC0.

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