# MWCCS Covid-19 Supplement Activities

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $110,256

## Abstract

ABSTRACT
COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12
million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild,
moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other
organ and blood systems. Studies document more severe disease and higher mortality among people who are
older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However,
there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV
(PWH). There is also little data to guide prevention and treatment recommendations for this population, many
of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also
the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial
racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS-
WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and
women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge
gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and
racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression
to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich
biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney,
neurocognitive, and physical function, body composition and has performed cohort-wide genome association
studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among
US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease
acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short-
term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and
geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.

## Key facts

- **NIH application ID:** 10226756
- **Project number:** 3U01HL146333-02S3
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Roger Detels
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $110,256
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10226756

## Citation

> US National Institutes of Health, RePORTER application 10226756, MWCCS Covid-19 Supplement Activities (3U01HL146333-02S3). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10226756. Licensed CC0.

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