# Mechanisms that underlie poorer binaural outcomes in patients with asymmetrical hearing and bilateral cochlear implants

> **NIH NIH F31** · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $31,234

## Abstract

PROJECT SUMMARY/ABSTRACT
 Binaural hearing allows listeners to better understand speech in noise and localize sounds. This proposal
aims to develop a clearer understanding of the mechanisms that contribute to poorer binaural hearing abilities
in patients with cochlear implants. The proposed experiments investigate the effects of poor hearing outcomes
in one or both ears on speech perception and computational modeling of binaural processing in the brainstem.
 Abnormal speech perception with poor speech outcomes in one or both ears may contribute to poorer
speech understanding in noise. Aim 1 will investigate differences in speech perception in cases of simulated or
actual asymmetrical hearing, when speech understanding is poor in one or both ears. Factors that affect cochlear
implant patients, namely the fidelity of temporal information conveyed by cochlear implant electrodes, will be
simulated in younger and older listeners with normal hearing to account for aging effects. By testing participants
with normal hearing and cochlear implants, results will have important implications for changes in perception
with disease and perception with normal hearing.
 Poor encoding of binaural cues with asymmetrical hearing may result in reduced sensitivity to binaural
cues and poorer sound localization performance. Aim 2 will develop a computational model of binaural encoding
in the brainstem where one or both sides are deteriorated as in hearing impairment to predict the effects of
hearing loss and cochlear implant stimulation on binaural processing. This approach will allow for an explanation
of perceptual results in terms of the physiological mechanisms involved in the brainstem. Specific factors that
affect patients with hearing loss and patients that use cochlear implants can be modeled and assessed
separately to account for changes that occur along the binaural pathway.
 The training program will result in the development of the following specific scientific skills: (1) sound
processing for cochlear implant simulations and speech perception experiments, (2) programming cochlear
implants for direct connect experiments, (3) development and testing of computational models of binaural
processing, and (4) ability to make electrophysiological recordings and understand their limitations. Each of these
skills is critical to the applicant’s development as a scientist and future career in binaural hearing research. With
these and other existing research skills, it will be possible to establish an independent and productive line of
research concerning binaural hearing outcomes for adults with bilateral cochlear implants and normal hearing.
 Good binaural hearing improves the lives of patients. The results of the projects in this proposal will shed
light on the perceptual and physiological problems that limit binaural hearing abilities in listeners with bilateral
cochlear implants. Ultimately, these results will be important in understanding the limitations to binau...

## Key facts

- **NIH application ID:** 10226859
- **Project number:** 5F31DC018483-02
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** SEAN R ANDERSON
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $31,234
- **Award type:** 5
- **Project period:** 2020-06-01 → 2022-04-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10226859

## Citation

> US National Institutes of Health, RePORTER application 10226859, Mechanisms that underlie poorer binaural outcomes in patients with asymmetrical hearing and bilateral cochlear implants (5F31DC018483-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10226859. Licensed CC0.

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