# Structures, Dynamics and Signaling Mechanisms of Modular Photoreceptors

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $160,000

## Abstract

Project Summary
The goal of this administrative supplement is to acquire key instruments for setting up an in-house sample
preparation system to facilitate dynamic studies of large photoreceptor molecules using the cryoEM single
particle analysis method. Leveraging on the progress made in the first two years of this funding period, this
system will enable direct observation and analytical deconvolution of light-induced conformational dynamics
in photoreceptor particles that cannot be obtained by other methods. This experimental capability will allow
controlled photoexcitation of light sensitive systems, and ensure the sample quality and consistency critical to
the success of dynamic experiments. It will strengthen our ongoing effort of the parent grant that centers on
the mechanistic understanding of light signaling and allosteric regulation in modular photoreceptors.

## Key facts

- **NIH application ID:** 10227480
- **Project number:** 3R01EY024363-06S1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Xiaojing Yang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $160,000
- **Award type:** 3
- **Project period:** 2014-05-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10227480

## Citation

> US National Institutes of Health, RePORTER application 10227480, Structures, Dynamics and Signaling Mechanisms of Modular Photoreceptors (3R01EY024363-06S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10227480. Licensed CC0.

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