# USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub

> **NIH NIH U01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $2,548,474

## Abstract

PROJECT SUMMARY
The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of
craniofacial development and dysmorphologies, and to disseminate these datasets to the wider craniofacial
research community. The FaceBase 3 Data Management and Integration Hub builds on the existing and
successful scientific and technical team that has lead the development, deployment, operation and community
engagement of the FaceBase 2 data hub. Looking forward to the future impact of the FaceBase Consortium, we
face major challenges that include: (1) how to annotate large datasets to empower the biomedical research
community; (2) how to improve data integration and facilitate data search and retrieval from the hub; (3) how to
use the data from FaceBase to design studies and otherwise inform our future research; and (4) how to translate
our knowledge from animal model studies to improve human craniofacial health. Importantly, the projects we
propose here are designed to address these issues as we develop anatomy-based comprehensive data search
and display, incorporate additional datasets from the community, and promote the usage of FaceBase data. In
pursuit of these goals, we propose the following three Specific Aims: Specific Aim 1: Create a FAIR data
repository and resource hub for the craniofacial research community. Specific Aim 2: Promote and enable data
contributions to FaceBase by NIDCR-supported researchers. Specific Aim 3: Foster a community of active
FaceBase users through outreach activities and dissemination of new features and available datasets. We will
create educational materials and provide training opportunities for the next generation of craniofacial
researchers. Ultimately, our proposed projects will not only contribute to our comprehensive understanding of
the molecular regulatory mechanisms of craniofacial development but will also demonstrate how others can use
the datasets from the FaceBase Hub to develop innovative approaches to improve human health.

## Key facts

- **NIH application ID:** 10227702
- **Project number:** 5U01DE028729-03
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Yang Chai
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,548,474
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10227702

## Citation

> US National Institutes of Health, RePORTER application 10227702, USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub (5U01DE028729-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10227702. Licensed CC0.

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