# Core 2: Biostatistics and Informatics Core

> **NIH NIH P50** · CASE WESTERN RESERVE UNIVERSITY · 2021 · $232,501

## Abstract

PROJECT SUMMARY/ABSTRACT 
The Case GI SPORE Biostatistics and Informatics Core will interact with all SPORE investigators to develop and 
apply appropriate analysis methods, study designs and secure databases to most efficiently achieve project 
goals. We will work closely with investigators to ensure that research questions lead to experiments with 
quantifiable goals and testable hypotheses. In addition the Case GI SPORE Biostatistics and Informatics Core 
will provide infrastructure and oversight for secure management of all study data, working closely with the 
Biospecimen Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our 
specific aims are: (1) To provide support to Case GI SPORE investigators in the design, conduct, analysis and 
reporting of results from Case GI SPORE studies and (2) To provide secure and accessible database systems 
to facilitate reliable and reproducible impactful results for all Case GI SPORE investigators. The Biostatistics 
and Informatics Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case 
Western Reserve University (CWRU) School of Medicine and the Institute for Computational Biology (ICB) at 
CWRU. Drs. Jill Barnholtz-Sloan and Jonathan Haines will co-direct the Core. The Biostatistics and 
Informatics Core will serve as a centralized resource for all investigators involved in the Case GI SPORE, 
including the leaders of the 4 translational research projects, Developmental Research Program (DRP) 
investigators, Career Enhancement Program (CEP) investigators and leaders of the Biospecimen Core. The 
Core will assist investigators with all facets of statistical design, analysis and interpretation. Established as 
well as novel tailored analytic methods are available to promote scientific discovery for GI cancers within the 
Core. Core personnel will interact with SPORE investigators in all stages of research, from the formulation of 
the research questions, through experimental design, data management, data analysis (including outcomes 
analysis), interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will 
also facilitate access to secure and accessible database systems in order to assist with statistical 
analysis, discovery and collaboration. The Core will assist all investigators with development, management and 
reliability of their project data and will also integrate information across databases, such as incorporating clinical 
and experimental data with biospecimen data as provided by the Biospecimen Core. The Biostatistics and 
Informatics Core will provide a natural foundation for cross-pollination among the projects and Cores, the 
Core personnel collaborating with all project investigators and Core directors.

## Key facts

- **NIH application ID:** 10227751
- **Project number:** 5P50CA150964-10
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Thomas Louis LaFramboise
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $232,501
- **Award type:** 5
- **Project period:** 2011-09-14 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10227751

## Citation

> US National Institutes of Health, RePORTER application 10227751, Core 2: Biostatistics and Informatics Core (5P50CA150964-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10227751. Licensed CC0.

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