# Topic 393: Integrated Photonic Biosensor for Precision Oncology Dose Measurements

> **NIH NIH N43** · INTELLIGENT FIBER OPTIC SYSTEMS CORP · 2020 · $55,000

## Abstract

Radiation therapy is a widely used primary treatment for multiple malignancies. However, physical dose measurement is
not an effective approach as the biological response of different patients or even different types of cancers are very
different for the same physical dose. Moreover, diseased tissue and normal organ radiation sensitivities also vary.
Existing medical devices (physical dosimeters) do not satisfy all the metrics for assessing biological response to radiation
therapy, especially in a point-of-care manner. IFOS and Stanford University are developing a rapid, portable, easy-to-use
and quantitative dose measurement method – comprising a portable handheld sensor and a novel nanoprobe for rapid,
real-time in-situ imaging of cancerous tissue. The probe is designed to detect Reactive Oxygen and Nitrogen Species
(RONS) generated due to radiation and charge particle therapy. The innovation will provide greatly enhanced imaging
capabilities to oncologists in radiation treatment monitoring.

## Key facts

- **NIH application ID:** 10227889
- **Project number:** 75N91019C00051-P00002-9999-1
- **Recipient organization:** INTELLIGENT FIBER OPTIC SYSTEMS CORP
- **Principal Investigator:** Richard Black
- **Activity code:** N43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $55,000
- **Award type:** —
- **Project period:** 2019-09-16 → 2020-12-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10227889

## Citation

> US National Institutes of Health, RePORTER application 10227889, Topic 393: Integrated Photonic Biosensor for Precision Oncology Dose Measurements (75N91019C00051-P00002-9999-1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10227889. Licensed CC0.

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