# Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement

> **NIH NIH R01** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 2021 · $15,896

## Abstract

PROJECT SUMMARY
In the project, “Drinking Levels (Binge, Volume) And Alcohol Consequences: Using National Data To Identify
Clinical Trial Endpoints” (R01AA025309), epidemiologic data have been used to investigate the relationship of
heavy drinking indicators to the risk for alcohol dependence and other drinking consequences. Much of the work
for this study has focused on whether non-abstinent drinking reductions improve how individuals feel and function
across a broad range of domains. In the project, drinking reduction has primarily been measured by the World
Health Organization (WHO) risk drinking levels: very high risk, high risk, moderate risk, and low risk. These
represent gender-specific average volumes of ethanol consumed per day. Health outcomes have covered a
broad range of domains, including alcohol dependence (occurrence, persistence), impaired functioning, liver
disease, AUDIT-C screening scores, drug use disorders, depressive/anxiety disorders, and cardiovascular
disease. The project has also contributed to papers addressing similar issues regarding WHO risk drinking levels
in treatment data from randomized clinical trials. However, the study did not include the relationship of WHO risk
drinking levels to additional important variables that are often highly related to drinking levels and also to the
outcomes already analyzed. In particular, these additional variables include tolerance to alcohol; family history
of alcohol use disorders; and sexual minority status. In addition, no information exists on whether experiencing
discrimination as a member of a sexual minority group moderates the relationship of sexual minority status to
WHO risk drinking levels. Therefore, Aim 1 of this administrative supplement is to conduct these additional
analyses on WHO risk drinking levels and alcohol tolerance, family history of alcohol use disorders, and sexual
minority status, which will involve unanticipated costs. Furthermore, no document exists that summarizes extant
information on the epidemiology of heavy drinking and alcohol use disorders (AUD), including the findings of the
project, in a user-friendly form for healthcare providers. Healthcare providers are often not knowledgeable about
the epidemiology of heavy drinking and AUD and the benefits of non-abstinent drinking reduction. Providing this
knowledge to them may help them do improved screening and brief interventions with their patients. Therefore,
Aim 2 of this administrative supplement is to prepare a document for healthcare providers that summarizes
accurate knowledge about the epidemiology of heavy drinking and alcohol use disorders in a manner that will
be easy for the healthcare providers to understand and use. This work will also involve unanticipated costs.

## Key facts

- **NIH application ID:** 10228425
- **Project number:** 3R01AA025309-05S1
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **Principal Investigator:** DEBORAH S HASIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $15,896
- **Award type:** 3
- **Project period:** 2016-03-10 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10228425

## Citation

> US National Institutes of Health, RePORTER application 10228425, Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement (3R01AA025309-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10228425. Licensed CC0.

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