# Racial/Ethnic Disparities in Heart Failure: A Cross Cohort Collaboration

> **NIH NIH R01** · KENT COUNTY MEMORIAL HOSPITAL · 2021 · $766,081

## Abstract

ABSTRACT
Heart failure (HF), and its subtypes defined by preserved (HFpEF), reduced (HFrEF) or mid-range (HFmrEF)
ejection fraction are a major and growing public health problem. The long term goal of this project is to better
understand the health disparities regarding HF and define effective preventive measures that may reduce
these disparities. We propose to pool data from 10 large longitudinal cohort studies to examine race/ethnic
and sex disparities in developing HF, its subtypes, and its prognosis. The harmonized data will include over
130,028 men and women with over 8975 similarly-adjudicated prospective HF outcomes, representing a wide
spectrum of ages, race/ethnicities, and geographic regions of the United States. This cross-cohort
collaboration will provide a unique opportunity to conduct a comprehensive evaluation of sex and racial/ethnic
health disparities in HF. Causal mediation analysis techniques will be used to estimate the degree to which
single and multi-factor lifestyle and clinical interventions could potentially reduce health disparities in HF. In our
phenomapping aim, we will define unique clinically relevant phenotypes of HF based upon cohort data that is
also commonly present in medical records for enhanced generalizability, including age, race/ethnicity, sex,
clinical signs, symptoms, biomarkers, ejection fraction, physiologic measures, and co-morbidities; we will also
evaluate HF phenotype associations with CVD and all-cause mortality.

## Key facts

- **NIH application ID:** 10228457
- **Project number:** 1R01HL150170-01A1
- **Recipient organization:** KENT COUNTY MEMORIAL HOSPITAL
- **Principal Investigator:** NORRINA Bai ALLEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $766,081
- **Award type:** 1
- **Project period:** 2021-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10228457

## Citation

> US National Institutes of Health, RePORTER application 10228457, Racial/Ethnic Disparities in Heart Failure: A Cross Cohort Collaboration (1R01HL150170-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10228457. Licensed CC0.

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