# Protocol Review & Monitoring System (PRMS)

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $72,189

## Abstract

PROJECT SUMMARY - PROTOCOL REVIEW AND MONITORING SYSTEM 
The Protocol Review and Monitoring System (PRMS) provides scientific oversight of all clinical and 
translational research performed at the Albert Einstein Cancer Center (AECC). PRMS functions are carried out 
by the Protocol Review and Monitoring Committee (PRMC), a multidisciplinary group whose members have 
expertise and experience in therapeutics, drug development, and translational science. The PRMC performs a 
complete scientific, feasibility, and administrative review of all institutional investigator-initiated and industry- 
sponsored cancer-related protocols. The PRMC does not duplicate traditional peer review, which includes 
peer-reviewed protocols supported by the various NIH mechanisms, other approved funding agencies, and 
clinical research protocols supported by NCI's Cancer Therapy Evaluation Program or Cancer Control Protocol 
Review Committee. All NCI-sponsored protocols that have undergone prior peer review undergo an expedited 
administrative review for feasibility and overlapping eligibility with other trials. Functions of the PRMC are 
complementary to the Institutional Review Board (IRB), which focuses on the protection of human subjects, 
and separate from those of the AECC Data Safety Monitoring Committee (DSMC). The PRMC ensures that all 
trials have appropriate data safety and monitoring plans in place; data and safety monitoring functions are the 
responsibility of the DSMC. The system for initial review comprises 2-stages, starting first with approval by a 
disease or modality-oriented clinical research leader (CRL) and Associate Director for Clinical Research, 
followed by review by the PRMC. This 2-stage review process increases efficiency by (i) reducing staff effort in 
developing protocols and PRMC application materials of lesser scientific merit, (ii) reducing the time from 
concept approval to protocol activation, and (iii) decreasing the volume of protocols reviewed by the 
committee. Over the last 3-years (7/1/15-6/30/18), there were 442 new protocols activated, including 306 
intervention (15% institutional) and 136 non-intervention (85% institutional).

## Key facts

- **NIH application ID:** 10228653
- **Project number:** 5P30CA013330-49
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Sanjay Goel
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $72,189
- **Award type:** 5
- **Project period:** 1997-06-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10228653

## Citation

> US National Institutes of Health, RePORTER application 10228653, Protocol Review & Monitoring System (PRMS) (5P30CA013330-49). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10228653. Licensed CC0.

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