# Tracking autobiographical thoughts: a smartphone-based approach to the detection of cognitive and neural markers of Alzheimer's disease risk

> **NIH NIH R56** · UNIVERSITY OF ARIZONA · 2020 · $642,211

## Abstract

In line with the mission of the National Institute on Aging, the proposed studies seek to use a mutli-method
approach to improve early detection of Alzheimer’s disease (AD)-related cognitive aberrations, and to mitigate
existing geographic, socioeconomic and health-related barriers in AD research by making these markers more
widely accessible. Central to our project are two of our team’s mobile smartphone apps, which we will use to
longitudinally track autobiographical thoughts in everyday life. Extending our previous work in this area, our
proposed studies will a) examine how real-world autobiographical thoughts in cognitively unimpaired young,
middle-aged, and older adults are altered by the presence of a key genetic risk factor for AD, namely the
apolipoprotein E e4 allele (APOE4), b) uncover the neural underpinnings of such alterations among older adults
and relationships between cognitive and neural changes over time, c) reveal the prognostic potential of
measuring autobiographical thoughts in older adults for a host of longitudinal health outcomes suggestive of the
preclinical progression of AD, and d) shed light on neurocognitive characteristics associated with normal “low-
risk” aging. MPIs Dr. Grilli and Dr. Andrews-Hanna have formed a team of researchers with expertise in
naturalistic assessment of cognition, autobiographical thought, resting state functional connectivity, healthy and
pathological aging, and longitudinal analysis of large datasets. Utilizing our team’s interdisciplinary expertise, we
will execute an innovative two-pronged project harnessing in-lab, at-home, and online assessment methods that
will evaluate the relationships of AD risk and aging to the autobiographical thoughts of >1,225 genotyped
cognitively unimpaired adults, with a subset completing additional in-lab experimental tests, neuroimaging, and
longitudinal follow-up. In Aim 1, we will test the hypothesis that autobiographical thoughts assessed in real-world
settings are particularly sensitive to increased AD risk, as measured by APOE4, among cognitively unimpaired
adults, and that alterations in resting state functional connectivity of the default network mediate these AD risk-
cognitive relationships. Aim 2 tests the hypothesis that measures of real-world autobiographical thoughts are
better predictors than lab-based tests of future neural (i.e., default network resting state functional connectivity),
cognitive, affective (i.e., depressive symptoms), and functional changes (i.e., instrument and social functioning)
suggested by preclinical AD acceleration. Aim 3 uncovers changes in autobiographical thoughts and their
underlying neural architecture that emerge from normal (i.e., low AD-risk) aging. This project is both significant
and innovative; to our knowledge, it will be the first to use smartphones to track autobiographical thoughts as a
means to identify AD risk, despite strong theoretical tenets and preliminary evidence that doing so could improve
prec...

## Key facts

- **NIH application ID:** 10228998
- **Project number:** 1R56AG068098-01
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Jessica Renee Andrews-Hanna
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $642,211
- **Award type:** 1
- **Project period:** 2020-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10228998

## Citation

> US National Institutes of Health, RePORTER application 10228998, Tracking autobiographical thoughts: a smartphone-based approach to the detection of cognitive and neural markers of Alzheimer's disease risk (1R56AG068098-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10228998. Licensed CC0.

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