# Computational Core

> **NIH NIH P01** · BOSTON CHILDREN'S HOSPITAL · 2021 · $87,000

## Abstract

Summary
Core C, Kepler
The overall goal of the research program is to design immunogens that elicit a broadly neutralizing response
by applying the knowledge gained through the analysis of B-cell ontogeny following influenza-virus vaccination
or infection. The achievement of this goal will require substantial use of methods from computational biology
and statistics to effectively extract the relevant information from the large datasets that will be generated in
pursuit of this goal. The primary objective of Core C (Computational Biology) is to provide the methods,
expertise, and software to meet these essential needs.
In particular, Core C will provide
1. Support to the P01 investigators for the analysis of immunoglobulin sequencing data,
2. Support for statistical data analysis including epitopic/paratopic distance and correlates of antibody
 function, and
3. A data management system for the organization and analysis of data generated within the program.

## Key facts

- **NIH application ID:** 10229501
- **Project number:** 5P01AI089618-10
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Thomas B Kepler
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $87,000
- **Award type:** 5
- **Project period:** 2011-08-01 → 2023-04-06

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10229501

## Citation

> US National Institutes of Health, RePORTER application 10229501, Computational Core (5P01AI089618-10). Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/grant/nih/10229501. Licensed CC0.

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